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TheYangZhangLabHomeResearchCOVID-19ServicesPublicationsPeopleTeachingJobOpeningNewsForum-->OnlineServices9679;I-TASSER9679;I-TASSER-MTD9679;C-I-TASSER9679;CR-I-TASSER9679;QUARK9679;C-QUARK9679;LOMETS9679;MUSTER9679;CEthreader9679;SEGMER9679;DeepFold9679;DeepFoldRNA9679;FoldDesign9679;COFACTOR9679;COACH9679;MetO9679;TripletGO9679;StarFunc9679;IonCom9679;FG-MD9679;ModRefiner9679;REMO9679;DEMO9679;DEMO-EM9679;DMFold9679;SPRING9679;COTH9679;Threpp9679;PEPPDas Yang Zhang LaborI9679;BSpred9679;ANGLOR9679;EDock9679;BSP-SLIM9679;SAXSTER9679;FUpred9679;ThreaDom9679;ThreaDomEx9679;EvoDesign9679;BindProf9679;BindProfX9679;SSIPe9679;GPCR-I-TASSER9679;MELLAN9679;ResQ9679;STRUM9679;DAMpred9679;TM-score9679;TM-align9679;US-align9679;MM-align9679;RNA-align9679;NW-align9679;LS-align9679;EDTSurf9679;MVP9679;MVP-Fit9679;SPICKER9679;HAAD9679;PSSpred9679;3DRobot9679;MR-REX9679;I-TASSER-MR9679;SVMSEQ9679;NeBcon9679;ResPRE9679;TripletRes9679;DeepPotential9679;WDL-RF9679;ATPbind9679;DockRMSD9679;DeepMSA9679;FASPR9679;EMDas Yang Zhang Labor-Refiner9679;GPU-I-TASSER9679;BioLiP9679;E.coli9679;GLASS9679;GPCR-HGmod9679;GPCR-RD9679;GPCR-EXP9679;Tara-3D9679;TM-fold9679;DEDas Yang Zhang LaborCOYS9679;POTENTIAL9679;RW/RWplus9679;EvoEF9679;HPSF9679;THE-DB9679;ADDRESS9679;Alpaca-Antibody9679;CASP79679;CASP89679;CASP99679;CASP109679;CASP119679;CASP129679;CASP139679;CASP14YangZhang'sResearchGroupDepartmentofComputationalMedicineandBioinformaticsDepartmentofBiologicalChemistryUniversityofMichiganMedicalSchool100WashtenawenueAnnArbor,MI-2218Phone:(734)647-1549Fax:(734)615-6553Email:zhanglabzhanggroup.orgWeareinterestedin:ProteinStructurePredictionProteinDesignandProteinEngineeringStructure-basedProteinFunctionAnnotationSNPMutationandGeneticDiseasesProtein-ProteinInteractionsLigandDockingandStructure-BasedDrugDesignDeterminingstructureandfunctionofproteinmoleculesisacornerstoneofmodernbiologyandmedicine.Oneofthemainfocusesofourlabistodevelopcomputationalmethodstopredict3-dimensionalstructureofproteinmoleculesfromaminoacidsequence,andtodeducethebiologicalfunctionsbasedonthesequence-to-structure-to-functionparadigm.Thesecondfocusofourlabistocombinecomputationalalgorithmsandbiochemistryexperimentstodesignnewproteinmoleculeswithenhancedfunctionalitybeyondnatureproteins.Wearealsoworkingonmodelingligand-proteinandprotein-proteininteractions,withparticularinterestinnewdrugscreeningtargetingGprotein-coupledreceptorsinthehumangenome(>>readmore...).ZhangLabnews:PREDICTIONCENTER.ORG(2022/12/15):AnupdatedversionofI-TASSER,D-I-TASSER,wasrankedastheNo.1serverinthe15thCASPexperiment,intwocategoriesofproteinstructurepredictionsincludingMulti-domainTargets,Single-domainTargets,andDMFoldwasrankedastheNo.1predictorinproteincomplexstructurepredictioncategory(i.e.,Multi-chainTargets)..CLARIVATE.COM(2022/11/18):YangZhangwasselectedasthe2022ThomsonReuters/ClarivateAnalyticsHighlyCitedResearcher..INF.NEWS(2022/05/13):ZhangYang'steamreportsanewalgorithmforproteinstructureconstructionfromcryo-EMimes.(>>readmoreZhangLabnews...)zhanglabzhanggroup.org|(734)647-1549|100Washtenawenue,AnnArbor,MI-2218