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Wolkens(RSEE)ReligionsRemoteSensingReportsReproductiveMedicine(Reprod.Med.)ResourcesRheumatoRisksRoboticsRuminantsSafetySciScientiaPharmaceutica(Sci.Pharm.)SclerosisSeedsSensorsSeparationsSexesSignalsSinusitisSmartCitiesSocialSciencesSociétéInternationaled’UrologieJournal(SIUJ)SocietiesSoftwareSoilSystemsSolarSolidsSpectroscopyJournalSportsStandardsStatsStressesSurfacesSurgeriesSurgicalTechniquesDevelopmentSustainabilitySustainableChemistrySymmetrySynBioSystemsTargetsTaxonomyTechnologiesTelecomTextilesThalassemiaReportsTherapeuticsThermoTimeandSpaceTomographyTourismandHospitalityToxicsToxinsTransplantologyTraumaCareTrendsinHigherEducationTropicalMedicineandInfectiousDisease(TropicalMed)UniverseUrbanScienceUroVaccinesVehiclesVenereologyVeterinarySciencesVibrationVirtualWorldsVirusesVisionWasteWaterWildWindWomenWorldWorldElectricVehicleJournal(WEVJ)YouthZoonoticDiseasesArticleTypeAllArticleTypesArticleReviewCommunicationEditorialAbstractBookReviewBriefCommunicationBriefReportCaseReportClinicopathologicalChallengeCommentCommentaryConceptPaperConferenceReportCorrectionCreativeDataDescriptorDiscussionEntryEssayExpressionofConcernExtendedAbstractFieldGuideGuidelinesHypothesisInterestingImesLetterNewBookReceivedObituaryOpinionPerspectiveProceedingPaperProjectReportProtocolRegisteredReportReplyRetractionShortNoteStudyProtocolSystematicReviewTechnicalNoteTutorialViewpoint  AdvancedSearch SectionSpecialIssueVolumeIssueNumberPe LogicalOperatorOperatorANDORSearchTextSearchTypeAllfieldsTitleAbstractKeywordsAuthorsAffiliationsDoiFullTextReferences add_circle_outlineremove_circle_outline  AtomsGordonDecompositionoftheMnetizabilityofaDiracOne-ElectronAtominanArbitraryDiscreteEnergyStateCatalystsRecentAdvancesinPhotocatalyticDegradationofTetracyclineAntibioticsAxiomsOnaGenericFractionalDerivativeAssociatedwiththeRiemann–LiouvilleFractionalIntegralAnimalsNativeComparedtoCitratedWholeBloodforCoulationTestinginHorsesNutrientsEggConsumptionand4-YearChangeinCognitiveFunctioninOlderMenandWomenRecentArticles attachmentSupplementarymaterial:SupplementaryFile1(ZIP,420KiB)18pes,4989KiB OpenAccessArticleEffectofBoilingTreatmentonLinoleicAcid-InducedOxidationofMyofibrillarProteininGrassCarpbyMengcongLiu,FuhuaLi,YuanTang,JichunZhao,XiaojuanLeiandJianMingFoods2024,13(24),4153;doi.org/10.3390/foods(registering DOI)-22Dec2024AbstractTheaimofthisstudywastoinvestigatethepromotionoflinoleicacid(OLA)-inducedmyofibrillarprotein(MP)oxidationbyboilingtreatment.TheeffectoftheboilingtreatmentongrasscarpMPoxidationinducedbyOLAwasinvestigated.Thetotalsulfhydrylcontent,fluorescenceintensity,[...]Readmore.Theaimofthisstudywastoinvestigatethepromotionoflinoleicacid(OLA)-inducedmyofibrillarprotein(MP)oxidationbyboilingtreatment.TheeffectoftheboilingtreatmentongrasscarpMPoxidationinducedbyOLAwasinvestigated.Thetotalsulfhydrylcontent,fluorescenceintensity,andaminoacidcontentwerereducedwiththeincreasingOLAconcentrationaftertheboilingtreatment,whiletheboiledoxidizedMP’scarbonylcontent(4.76±0.14nmol/mg)was2.14timeshigherthanthatofthenativeMP(2.22±0.02nmol/mg)atanOLAconcentrationof10mM.Additionally,thesecondarystructureofMPbecamemoredisordered,shiftingfromanα-helixtorandomcoilsandβ-turns.WhentheconcentrationofOLAwashigherthan5mM,boththesurfacehydrophobicityandwaterholdingcapacity(WHC)decreasedwiththeincreasingOLAconcentration.Furthermore,theboilingtreatmentledtoareductioninimmobilewaterandanincreaseinfreewatercontentintheMPgel.ThesefindingsestablishatheoreticalbasisforregulatingMPoxidationtoimprovefishqualityduringboiling.Fullarticle(ThisarticlebelongstotheSectionFoodEngineeringandTechnology)9658;9660;ShowFiguresGraphicalabstractFigure1---Figure2---Figure3---Figure4---Figure5---Figure64pes,183KiB OpenAccessEditorialRationalDesignofMetal-BasedPharmacologicallyActiveCompoundsbyIrenaKostovaInorganics2024,12(12),335;doi.org/10.3390/inorganics(registering DOI)-22Dec2024AbstractMetal-basedpharmacologicallyactivecompoundshebeenassociatedwithmanyprocessesinvivo,actingasactivesitesofmetalloproteins[...]Fullarticle(ThisarticlebelongstotheSpecialIssueRationalDesignofPharmacologicallyActiveMetal-BasedCompounds)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,214KiB)26pes,568KiB OpenAccessArticleYieldResponsestoTotalWaterInputfromIrrigationandRainfallinSixWheatCultivarsUnderDifferentClimaticZonesinEgyptbyAhmedFawzyElkot,YasserShabana,MahaL.Elsayed,SamirMahmoudSaleh,MahaA.M.Gadallah,BruceD.L.Fitt,BenjaminRichardandAimingQironomy2024,14(12),3057;doi.org/10.3390/ronomy(registering DOI)-21Dec2024AbstractInEgypt,wheatisthemostconsumedcerealgrain,anditsailabilityandaffordabilityareimportantforsocialstability.Irrigationplaysavitalroleinwheatcultivation,despiteintensecompetitionforwaterresourcesfromtheRiverNileacrossvarioussocietalsectors.Toexplore[...]Readmore.InEgypt,wheatisthemostconsumedcerealgrain,anditsailabilityandaffordabilityareimportantforsocialstability.Irrigationplaysavitalroleinwheatcultivation,despiteintensecompetitionforwaterresourcesfromtheRiverNileacrossvarioussocietalsectors.Toexplorehowgrainandabove-groundbiomassyieldsrespondtototalseasonalwaterinputfromsowingtomaturityinsixbreadwheatcultivars,eightfieldirrigationexperimentswereperformedatfourlocationsrepresentativeofthreero-climaticzonesintwoconsecutivecroppingseasons.Athree-replicatestrip-plotdesignwasusedwithcultivarsnestedwithinthemainplotsfeaturingfiveirrigationtreatments,rangingfromsixtotwoapplications.Overall,irrigationtreatmentsignificantlyaffectednineronomictraits.Comparedwiththesixirrigationapplicationstreatment(T1),thetwoirrigationapplicationstreatment(T5)decreasedthetimestoheadingandmaturityby6.6(7.3%)and8.6(6.3%)days,respectively.Similarly,T5reducedtheplantheightby14.9cm(14.3%),flleafareaby12.0cm2(27.2%),numberofspikespersquaremetreby77.7(20.1%),numberofkernelsperspikeby13.9(25.2%)andthousandgrainweightby10.0g(19.6%).T5alsodecreasedtheoverallmeangrainyieldandabove-groundbiomassyieldby2834.9(32.0%)and7910.4(32.86%)kg/ha,respectively.Thegrainyieldandabove-groundbiomassproductionwereconsistentlygreaterforallsixcultivarsatAlMataenahandSidsthanatNubariaandIsmailiainthetwocroppingseasons.Allsixcultivarsshowedsignificantlygreaterresponsestototalseasonalwaterinputforthegrainyieldandabove-groundbiomassatAlMataenahandIsmailia.Theseresultsemphasisethenecessityforchoosingregionswithfourablesoilandclimaticconditionstogrowwheatcultivarsthatrespondbettertoirrigationtoenhancethelarge-scaleproductionofwheatinEgypt.Thegrainandabove-groundbiomassyieldsweremostlylinearlyandpositivelyassociatedwiththetotalseasonalwaterinputforallsixcultivarsatallfourlocations.Thissuggeststhatmaintainingthecurrentirrigationscheduleofsixirrigationsisvalidandshouldbepractisedtomaximiseproductivity,particularlyinareassimilartothethreerepresentativero-climaticzonesinEgypt.Fullarticle(ThisarticlebelongstotheSectionWaterUseandIrrigation)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,KiB)14pes,2426KiB OpenAccessArticleMechanisticInsightsintotheAdenosineA1Receptor’sPositiveAllostericModulationforNon-OpioidAnalgesicsbyTalWeizmann,AbigailPearce,PeterGriffin,AchilleSchild,MarenFlaßhoff,PhilippGrossenbacher,MartinLochner,ChristopherA.Reynolds,GrahamLaddsandGiuseppeDeganuttiCells2024,13(24),2121;doi.org/10.3390/cells(registering DOI)-21Dec2024AbstractTheadenosineA1receptor(A1R)isapromisingtargetforpaintreatment.However,thedevelopmentoftherapeuticonistsishamperedbyadverseeffects,mainlyincludingsedation,bradycardia,hypotension,orrespiratorydepression.Recentlydiscoveredmoleculesabletoovercomethisimpedimentarethe[...]Readmore.TheadenosineA1receptor(A1R)isapromisingtargetforpaintreatment.However,thedevelopmentoftherapeuticonistsishamperedbyadverseeffects,mainlyincludingsedation,bradycardia,hypotension,orrespiratorydepression.RecentlydiscoveredmoleculesabletoovercomethisimpedimentarethepositiveallostericmodulatorMIPS521andtheA1R-selectiveonistBnOCPA,whicharebothpotentandpowerfulanalgesicswithfewersideeffects.WhileBnOCPAdirectlyactivatestheA1Rfromthecanonicalorthostericsite,MIPS521bindstoanallostericsite,actinginconcertwithorthostericadenosineandtuningitspharmacology.Giventheiroverlappingprofileinpainmodelsbutdistinctmechanismsofaction,wecombinedpharmacologyandmicrosecondmoleculardynamicssimulationstoaddressMIPS521andBnOCPAactivityandtheirreciprocalinfluencewhenboundtotheA1R.WeshowthatMIPS521changesadenosineandBnOCPAGproteinselectivityinoppositewaysandproposeastructuralmodelwhereTM7dynamicsaredifferentlyaffectedandinvolvedintheGproteinpreferencesofadenosineandBnOCPA.Fullarticle(ThisarticlebelongstotheSpecialIssueAdenosineandPurinergicReceptors:RegulationandEssentialRoleinHumanDisease)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure419pes,3914KiB OpenAccessArticleInvestigatingtheStructuralHealthofHigh-RiseBuildingsandItsInfluencingFactorsUsingSentinel-1SyntheticApertureRadarImery:ACaseStudyoftheGuangzhou–FoshanMetropolitanAreabyDiHuang,ZhixinQi,SuyaLin,YuzeGu,WenxuanSongandQianwenLvBuildings2024,14(12),4074;doi.org/10.3390/buildings(registering DOI)-21Dec2024AbstractUrbangrowthisincreasinglyshiftingfromhorizontalexpansiontoverticaldevelopment,resultinginskylinesdominatedbyhigh-risebuildings.Thepost-constructionoperationsandmaintenanceofthesebuildingsarecritical,requiringregularstructuralhealthmonitoring(SHM)toproactivelyidentifyandaddresspotentialsafetyconcerns.Interferometric[...]Readmore.Urbangrowthisincreasinglyshiftingfromhorizontalexpansiontoverticaldevelopment,resultinginskylinesdominatedbyhigh-risebuildings.Thepost-constructionoperationsandmaintenanceofthesebuildingsarecritical,requiringregularstructuralhealthmonitoring(SHM)toproactivelyidentifyandaddresspotentialsafetyconcerns.Interferometricsyntheticapertureradar(InSAR)hasproveneffectiveformonitoringbuildingsafety,butmoststudiesrelyonhigh-resolutionsyntheticapertureradar(SAR)imes.Thehighcostandlimitedcovereoftheseimesrestricttheiruseforlarge-scalemonitoring.Sentinel-1medium-resolutionSARimes,whicharefreelyailableandofferbroadcovere,makelarge-scaleSHMmorefeasible.However,studiesontheuseofSentinel-1SARimesforstructuralhealthmonitoring,especiallyatlargespatialscales,remainlimited.Toaddressthisgap,inthisstudy,Sentinel-1SARimesandPS-InSARtechnologyareproposedforperformingacomprehensivestructuralsafetyassessmentofsuperhigh-risebuildingsintheGuangzhou–FoshanMetropolitanArea(GFMA)andforanalyzingtheinfluencingfactors.Ourassessmentshowsthatwhiletheoverallstructuralsafetyofthesebuildingsissatisfactory,certainareas,includingPearlRiverNewTown,centralHuadudistrictinGuangzhou,andsoutheasternShundedistrictinFoshan,exhibitsuboptimalsafetyconditions.WeverifiedthesefindingsusingGNSSdataandon-siteinvestigations,confirmingthatSentinel-1SARimeryoffersreliableaccuracyformonitoringbuildingstructuralhealth.Furthermore,weidentifiedfactorssuchassettlementinsoftsoillayers,theconstructionofsurrounding(underground)infrastructure,andbuildinging,whichcouldpotentiallyimpactbuildingstructuralsafety.TheresultsdemonstratethatSentinel-1SARimesprovideareliable,rapid,andcost-effectivemethodforthelarge-scalemonitoringofbuildingstability,enhancingourunderstandingoftheunderlyingmechanismsandinformingstrategiestopreventpotentialsafetycrises,andalsoensuringthesustainabledevelopmentofsociety.Fullarticle(ThisarticlebelongstotheSpecialIssuePlanningforSustainableLandUseandBuiltEnvironmentinHigh-DensityCities)33pes,9160KiB OpenAccessArticleOptimizedAnalytical–NumericalProcedureforUltrasonicSludgeTreatmentforriculturalUsebyFilippoLanà,SalvatoreA.Pullano,GiovanniAngiulliandMarioVersaciAlgorithms2024,17(12),592;doi.org/10.3390/a(registering DOI)-21Dec2024AbstractThispaperpresentsanintegratedapproachbasedonphysical–mathematicalmodelsandnumericalsimulationstooptimizesludgetreatmentusingultrasound.Themainobjectiveistoimprovetheefficiencyofthepurificationsystembyreducingtheweightandmoistureofthepurificationsludge,thereforeensuring[...]Readmore.Thispaperpresentsanintegratedapproachbasedonphysical–mathematicalmodelsandnumericalsimulationstooptimizesludgetreatmentusingultrasound.Themainobjectiveistoimprovetheefficiencyofthepurificationsystembyreducingtheweightandmoistureofthepurificationsludge,thereforeensuringregulatorycomplianceandenvironmentalsustainability.Acoupledtemperature–humiditymodel,formulatedbypartialdifferentialequations,describesmaterials’thermalandwaterevolutionduringtreatment.Thenumericalresolution,implementedbythefiniteelementmethod(FEM),allowsthesimulationofthesystembehiorandtheoptimizationoftheoperatingparameters.Experimentalresultsconfirmthatultrasonictreatmentreducesthemoisturecontentofsludgebyupto20%andimprovesitsstability,makingitsuitableforriculturalapplicationsorfurthertreatment.Functionalcontrolsofsonicationandthereductionofwatercontentinthesludgecorrelatewiththeobtainedresults.Ultrasoundtreatmenthasbeenshowntodecreasethespecificweightofthesludgesamplebothinpretreatmentandtreatment,thereforeimprovingstabilization.Invariousexperimentalconditions,theweightofthesludgeisreducedbyamaximumofabout50%.Processedsludgetransformswasteintoaresourceforthericulturalsector.Treatmentprocesseshebeenoptimizedwithlow-energyoperatingprinciples.Additionally,besidesutilizingenergy-harvestingtechnology,plantoperatingprocesseshebeenoptimized,accountingforapproximately55%oftheconsumptionduetotheaerationofactivesludge.Inaddition,anextendedanalysisofultrasonicwepropationisproposed.Fullarticle(ThisarticlebelongstotheSpecialIssueNumericalOptimizationandAlgorithms:3rdEdition)11pes,283KiB OpenAccessArticleAssociationsofDepressionScorewithDialkylPhosphateMetabolitesinUrine:ACross-SectionalStudybyHaiZhaoandXuejunKangBrainSci.2024,14(12),1290;doi.org/10.3390/brainsci(registering DOI)-21Dec2024AbstractObjectives:Growingevidencesuggestsalinkbetweenorganophosphateinsecticidesanddepressiondisorder.Thesechemicalsaremetabolizedandsubsequentlyexpelledthroughtheurinarytract.Thepresentstudyaimstoinvestigatewhetherdialkylphosphatemetabolitesassociatewithdepressionscoreandseverityamongthegeneralpopulation.[...]Readmore.Objectives:Growingevidencesuggestsalinkbetweenorganophosphateinsecticidesanddepressiondisorder.Thesechemicalsaremetabolizedandsubsequentlyexpelledthroughtheurinarytract.Thepresentstudyaimstoinvestigatewhetherdialkylphosphatemetabolitesassociatewithdepressionscoreandseverityamongthegeneralpopulation.Methods:Thiscross-sectionalstudyuseddatafromtheNationalHealthandNutritionExaminationSurvey(NHANES).DepressionwasevaluatedbythePatientHealthQuestionnaire-9(PHQ-9).Allurinarydialkylphosphatemetaboliteswerequantitativelyanalyzed.Thesurvey’scomplexdesignparametersandsamplingweightswereconsidered.Results:3035eligibleindividualswereincluded.Theestimatedprevalenceofmildandmajordepressionwas18.3%(95%confidenceinterval[CI]:16.9–19.7%)and9.9%(95%CI:8.7–11.0%).Foreachincrementalunitinthelevelofurinarydimethylphosphate(DMP),individualswerefoundtoheahigherdepressionscoreof0.77andasignificantlyincreasedoddsratio(OR)of1.13(95%CI:1.12–1.13)formilddepressionand2.75(95%CI:2.74–2.76)formajordepression.Conclusions:Ourfindingsindicatepositiveandindependentassociationsbetweenurinarydialkylphosphatemetabolitesandanelevatedriskofdepressionamongthegeneralpopulation.Fullarticle(ThisarticlebelongstotheSectionPsychiatricDiseases)23pes,3211KiB OpenAccessArticleIntegrativeFrameworkforDecodingSpatialandTemporalDriversofLandUseChangeinMalaysia:StrategicInsightsforSustainableLandManementbyGuanqiongYe,KehaoChen,YiqunYang,ShanshanLiang,WenjiaHuandLiuyueHeLand2024,13(12),2248;doi.org/10.3390/land(registering DOI)-21Dec2024AbstractIdentifyingthedriversoflanduseandcoverchange(LUCC)iscrucialforsustainablelandmanement.However,understandingspatialdifferentiationandconductinginter-regionalcomparisonsofthesedriversremainslimited,particularlyinregionslikeMalaysia,wherecomplexinteractionsbetweenhumanactivitiesandnaturalconditions[...]Readmore.Identifyingthedriversoflanduseandcoverchange(LUCC)iscrucialforsustainablelandmanement.However,understandingspatialdifferentiationandconductinginter-regionalcomparisonsofthesedriversremainslimited,particularlyinregionslikeMalaysia,wherecomplexinteractionsbetweenhumanactivitiesandnaturalconditionsposesignificantchallenges.ThisstudypresentsanovelanalyticalframeworktoexaminethespatialvariationsandcomplexitiesofLUCC,specificallyaddressingthespatiotemporalpatterns,drivingfactors,andpathwaysofLUCCinMalaysiafrom2010to2020.Integratingthelandusetransfermatrix,GeoDetectormodel,andStructuralEquationModeling(SEM),werevealasignificantexpansionoffarmlandandurbanareasalongsideadeclineinforestcover,withnotableregionalvariationsinMalaysia.Human-drivenfactors,suchaspopulationgrowthandeconomicdevelopment,areidentifiedastheprimaryforcesbehindthesechanges,outweighingtheinfluenceofnaturalconditions.Critically,theinteractionsamongthesedriversexertastrongerinfluenceonLUCCdynamicsinMalaysiathananysinglefactoralone,suggestingincreasinglycomplexLUCCpredictionsinthefuture.Thiscomplexityemphasizestheurgencyofproactive,multifaceted,andregion-specificlandmanementpoliciestopreventirreversibleenvironmentaldegradation.ByproposingtailoredlandmanementstrategiesforMalaysia’sfivesubnationalregions,thisstudyaddressesspatialvariationsindriversandclimateresilience,offeringastrategicblueprintfortimelyactionthatcanbenefitMalaysiaandotherregionsfacingsimilarchallengesinsustainablelandmanement.Fullarticle(ThisarticlebelongstotheSpecialIssueLandUse/CoverChangeandItsImpactsonRegionalSustainableDevelopment)37pes,4111KiB OpenAccessArticleUrbanGrBitte 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WolkeneenInfrastructuresasToolsforUrbanInterconnection:TheCaseofSanBartolomeoDistrictinCliari,ItalybyLuigiMundula,ClaraDiFazio,FrancescaLeccisandMariaParadisoSustainability2024,16(24),;doi.org/10.3390/su6(registering DOI)-21Dec2024AbstractContemporaryurbanareasareoftencharacterizedbyvariousformsofencles,isolatedfromtheirsurroundinggeographicalcontext.Urbangreeninfrastructuresprovideanopportunitytoopentheseencles,establishingphysicalandfunctionalconnectionswiththebroadercity,whilealsocontributingtoclimatechangemitigation[...]Readmore.Contemporaryurbanareasareoftencharacterizedbyvariousformsofencles,isolatedfromtheirsurroundinggeographicalcontext.Urbangreeninfrastructuresprovideanopportunitytoopentheseencles,establishingphysicalandfunctionalconnectionswiththebroadercity,whilealsocontributingtoclimatechangemitigationandadaptation.ThisstudyexaminesthedistrictofSanBartolomeointheItaliancityofCliariasanexampleofanurbanencle,andemploysaparticipatoryplanningprocesstodesignaprojectthattransformsitintoahubopentothewidercitycommunity.Theresultisaneighborhoodshapedbyitscommunity,wheresocial,economic,andenvironmentalneedsarebalanced,fosteringconstantinteractionbetweenresidentsandthecityasawhole.Fullarticle(ThisarticlebelongstotheSpecialIssueASystemsApproachtoUrbanGreenspaceSystemandClimateChange)25pes,889KiB OpenAccessReviewRecyclingLithium-IonBatteries—Technologies,Environmental,HumanHealth,andEconomicIssues—Mini-SystematicLiteratureReviewbyGeaniTeodorMan,AndreeaMariaIordache,RamonaZgarogeaandConstantinNechitaMembranes2024,14(12),277;doi.org/10.3390/membranes(registering DOI)-21Dec2024AbstractGlobalconcernsaboutpollutionreduction,associatedwiththecontinuoustechnologicaldevelopmentofelectronicequipmentraiseschallengeforthefutureregardinglithium-ionbatteriesexploitation,use,andrecoverythroughrecyclingofcriticalmetals.Severalhumanandenvironmentalissuesarereported,includingrelateddiseasescausedby[...]Readmore.Globalconcernsaboutpollutionreduction,associatedwiththecontinuoustechnologicaldevelopmentofelectronicequipmentraiseschallengeforthefutureregardinglithium-ionbatteriesexploitation,use,andrecoverythroughrecyclingofcriticalmetals.Severalhumanandenvironmentalissuesarereported,includingrelateddiseasescausedbylithiumwaste.LithiuminLi-ionbatteriescanberecoveredthroughvariousmethodstopreventenvironmentalcontamination,andLicanbereusedasarecyclableresource.Classicaltechnologiesforrecoveringlithiumfrombatteriesareassociatedwithvariousenvironmentalissues,solithiumrecoveryremainschallenging.However,theemergenceofmembraneprocesseshasopenednewresearchdirectionsinlithiumrecovery,offeringhopeformoreefficientandenvironmentallyfriendlysolutions.Theseprocessescanbeintegratedintocurrentindustrialrecyclingflows,hingahighrecoverypotentialandpingthewayforamoresustainablefuture.Asecondmethod,biolexivation,iseco-friendly,butthispointillustratessignificantdrawbackswhenusedonanindustrialscale.WediscussedtoxicityinducedbymetalsassociatedwithLitoiron-oxidizingbacteria,whichneedsfurtherstudysinceitcauseslowrecyclingefficiency.OnemajorenvironmentalproblemisthelowefficiencyoftherecoveryofLifromthewatercycle,whichaffectsglobal-scalesafety.Still,electromembranescanofferpromisingsolutionsinthefuture,butthereisneededtoupdateregulationstoactualneedsforbothproducingandrecyclingLIB.Fullarticle(ThisarticlebelongstotheSectionMembraneApplicationsforEnergy)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,731KiB)16pes,3290KiB OpenAccessArticleCmpk2GeneandProteinExpressioninSalivaorSalivaryGlandsofDyslipidemicMicebyBaiyanZhang,AkiyoKawamoto,MasatoNakawa,YoshitomoHondaandKazuyaTakahashiAppl.Sci.2024,14(24),;doi.org/10.3390/app4(registering DOI)-21Dec2024AbstractSalivarybiomarkersarepromisingmoleculesfordinosingsystemicdiseases.Cytidine/uridinemonophosphatekinase2(CMPK2)isassociatedwithvarioussystemicdiseases.However,littleisknownabouttheroleoftheCMPK2geneinsalivaanddyslipidemia.Thisstudyinvestigatedtherelationshipbetweenserumlipid[...]Readmore.Salivarybiomarkersarepromisingmoleculesfordinosingsystemicdiseases.Cytidine/uridinemonophosphatekinase2(CMPK2)isassociatedwithvarioussystemicdiseases.However,littleisknownabouttheroleoftheCMPK2geneinsalivaanddyslipidemia.ThisstudyinvestigatedtherelationshipbetweenserumlipidlevelsandCmpk2mRNAexpressioninthesalivaofdyslipidemicmice.Additionally,immunofluorescencestainingwasemployedtoassessthelocalizationoftheCMPK2proteininthesubmandibulargland.Twotypesofdyslipidemicmicewereutilized:micefedahigh-fatandhigh-cholesterol(HFHC)dietandgeneticallydyslipidemicApoE-deficientmice.Themiceat9to46weekswereanalyzedforserumlipidlevels,Cmpk2mRNAexpressioninsaliva,andCMPK2proteinlocalizationinthesubmandibularglands.Bothdyslipidemicmicedisplayedelevatedlow-densitylipoproteincholesterolandtotalcholesterolinserum.ApoE-deficientmiceapparentlyexhibitedincreasedCmpk2expressioninsaliva.ImmunofluorescencestainingindicatedthatCMPK2proteinswereprimarilylocalizedintheserousacini,potentiallyassociatedwiththesecretionofCmpk2mRNAinsaliva.ThesefindingssuggestthatCmpk2mRNAincreasesandisdetectableinthesalivaofdyslipidemicmice,providingaviableexperimentalmodeltoassessthepotentialuseofCMPK2asabiomarkerfordyslipidemia.Fullarticle(ThisarticlebelongstotheSpecialIssueRecentAdvancementsinBiomarkersforNoncommunicableDiseases)13pes,475KiB OpenAccessArticleEffectsofDifferentPlantingDensitiesofSolanumnigrumL.ontheGrowthandCadmiumUptakeofYoungGrapevinesbyYuanxiangYang,QinfengZheng,JinWang,XiulanLv,DongLiang,RenyanLiaoandLijinLinronomy2024,14(12),3056;doi.org/10.3390/ronomy(registering DOI)-21Dec2024AbstractAbstract:WedeterminethebestplantingdensityofSolanumnigrumL.whenintercroppingwithyounggrapevinestodecreasecadmium(Cd)uptakebyyounggrapevines.Theeffectsofdifferentplantingdensities(plantspacing×rowspacing,incentimeters,anddesignatedas40×80,[...]Readmore.Abstract:WedeterminethebestplantingdensityofSolanumnigrumL.whenintercroppingwithyounggrapevinestodecreasecadmium(Cd)uptakebyyounggrapevines.Theeffectsofdifferentplantingdensities(plantspacing×rowspacing,incentimeters,anddesignatedas40×80,40×40,20×40and20×20,respectively)ofS.nigrumonthegrowthandCduptakeofyounggrapevineswerestudied.The40×80and40×40treatmentsincreasedthebiomass,photosyntheticpigmentcontentandphotosynthesisofyounggrapevines,whilethe20×40and20×20treatmentsdecreasedthesetraitscomparedwiththemonoculture.Withincreasingintercroppingdensity,theantioxidantenzymeactivityofbothplantspeciesincreased.IntercroppingwithS.nigrumdecreasedtheCdcontentinyounggrapevines,andthe40×80,40×40,20×40and20×20treatmentsdecreasedtheshootCdcontentinyounggrapevinesby20.89%,26.11%,38.12%and45.95%,respectively,comparedwiththemonoculture.Additionally,increasingtheintercroppingdensityincreasedtheCdcontentandextractionofS.nigrum.Thus,intercroppingyounggrapevinewithS.nigrumcandecreaseCduptakeinyounggrapevineswhileremediatingsoilCd-contamination,andthemostoptimaltreatmentis20×20inthisexperiment.Fullarticle(ThisarticlebelongstotheSectionInnovativeCroppingSystems)83pes,KiB OpenAccessReviewAReviewofLargeLangueModels:FundamentalArchitectures,KeyTechnologicalEvolutions,InterdisciplinaryTechnologiesIntegration,OptimizationandCompressionTechniques,Applications,andChallengesbySongyueHan,MingyuWang,JialongZhang,DongdongLiandJunhongDuanElectronics2024,13(24),5040;doi.org/10.3390/electronics(registering DOI)-21Dec2024AbstractLargelanguemodel-relatedtechnologiesheshownastonishingpotentialintaskssuchasmachinetranslation,textgeneration,logicalreasoning,taskplanning,andmultimodalalignment.Consequently,theirapplicationshecontinuouslyexpandedfromnaturallangueprocessingtocomputervision,scientificcomputing,andotherverticalindustryfields.[...]Readmore.Largelanguemodel-relatedtechnologiesheshownastonishingpotentialintaskssuchasmachinetranslation,textgeneration,logicalreasoning,taskplanning,andmultimodalalignment.Consequently,theirapplicationshecontinuouslyexpandedfromnaturallangueprocessingtocomputervision,scientificcomputing,andotherverticalindustryfields.Thisrapidsurgeinresearchworkinashortperiodposessignificantchallengesforresearcherstocomprehensivelygrasptheresearchdynamics,understandkeytechnologies,anddevelopapplicationsinthefield.Toaddressthis,thispaperprovidesacomprehensivereviewofresearchonlargelanguemodels.First,itorganizesandreviewstheresearchbackgroundandcurrentstatus,clarifyingthedefinitionoflargelanguemodelsinbothChineseandEnglishcommunities.Second,itanalyzesthemainstreaminfrastructureoflargelanguemodelsandbrieflyintroducesthekeytechnologiesandoptimizationmethodsthatsupportthem.Then,itconductsadetailedreviewoftheintersectionsbetweenlargelanguemodelsandinterdisciplinarytechnologiessuchascontrastivelearning,knowledgeenhancement,retrievalenhancement,hallucinationdissolution,recommendationsystems,reinforcementlearning,multimodallargemodels,andents,pointingoutvaluableresearchideas.Finally,itorganizesthedeploymentandindustryapplicationsoflargelanguemodels,identifiesthelimitationsandchallengestheyface,andprovidesanoutlookonfutureresearchdirections.Ourreviewpaperaimsnotonlytoprovidesystematicresearchbutalsotofocusontheintegrationoflargelanguemodelswithinterdisciplinarytechnologies,hopingtoprovideideasandinspirationforresearcherstocarryoutindustryapplicationsandthesecondarydevelopmentoflargelanguemodels.Fullarticle(ThisarticlebelongstotheSpecialIssueRecentAdvancesinLargeLangueModels)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure14---Figure15---Figure16---Figure17---Figure18---Figure19---Figure20---Figure21---Figure22---Figure23---Figure24---Figure25---Figure26---Figure27---Figure28---Figure29---Figure30---Figure31---Figure32---Figure33---Figure34---Figure35---Figure36attachmentSupplementarymaterial:SupplementaryFile1(ZIP,459KiB)16pes,2393KiB OpenAccessArticleFullyAutomatedAssessmentofCardiacChamberVolumesandMyocardialMassonNon-ContrastChestCTwithaDeepLearningModel:ValidationainstCardiacMRbyRamonaSchmitt,ChristopherL.Schlett,JonathanI.Sperl,SaikiranRapaka,AthiraJ.Jacob,ManuelHein,MuhammadTahaHar,PhilippRuile,DirkWestermann,MartinSoschynski,FabianBambergandChristopherSchuppertDinostics2024,14(24),2884;doi.org/10.3390/dinostics(registering DOI)-21Dec2024AbstractBackground:Tovalidatetheautomatedquantificationofcardiacchambervolumesandmyocardialmassonnon-contrastchestCTusingcardiacMR(CMR)asareference.Methods:Weretrospectivelyincluded53consecutivepatientswhoreceivednon-contrastchestCTandCMRwithinthreeweeks.Adeep[...]Readmore.Background:Tovalidatetheautomatedquantificationofcardiacchambervolumesandmyocardialmassonnon-contrastchestCTusingcardiacMR(CMR)asareference.Methods:Weretrospectivelyincluded53consecutivepatientswhoreceivednon-contrastchestCTandCMRwithinthreeweeks.Adeeplearningmodelcreatedcardiacsegmentationsonaxialsoft-tissuereconstructionsfromCT,coveringallfourcardiacchambersandtheleftventricularmyocardium.SegmentationsonCMRcineshort-axisandlong-axisimesservedasareference.Standardestimatesofdinosticaccuracywerecalculatedforventricularvolumesatend-diastoleandend-systole(LVEDV,LVESV,RVEDV,RVESV),leftventricularmass(LVM),andatrialvolumes(LA,RA)atventricularend-diastole.Aqualitativeassessmentnotedsegmentationissues.Results:ThedeeplearningmodelgeneratedCTmeasurementsfor52ofthe53patients(98%).BasedonCMRmeasurements,theereLVEDVwas166±64mL,RVEDVwas144±51mL,andLVMwas115±39g.TheCTmeasurementscorrelatedwellwithCMRmeasurementsforLVEDV,LVESV,andLVM(r=0.85,r=0.84,andr=0.91;allp<0.001)andRVEDVandRVESV(r=0.82andr=0.84;bothp<0.001),andmoderatelywellwithLAandRA(r=0.77andr=0.67;bothp<0.001).AbsolutereementslikewiseforedLVEDV,LVESV,andLVM.ECG-gatingdidnotrelevantlyinfluencetheresults.TheCTresultscorrectlyidentified7/15LVand1/1RVasdilated(oneandsixfalsepositives,respectively).Majorqualitativeissueswerefoundinthreecases(6%).Conclusions:Automatedcardiacchambervolumeandmyocardialmassquantificationonnon-contrastchestCTproducedviablemeasurementsinthisretrospectivesample.RelevanceStatement:Anautomatedcardiacassessmentonnon-contrastchestCTprovidesquantitativemorphologicaldataontheheart,enablingapreliminaryorganevaluationthataidsinincidentallyidentifyingat-riskpatientswhomaybenefitfromamoretargeteddinosticworkup.Fullarticle(ThisarticlebelongstotheSpecialIssueCardiothoracicIming:DinosticsandModernTechniques—2ndEdition)23pes,1204KiB OpenAccessArticleRiverbedAdjustmentsinGrel–SandReachesImmediatelyDownstreamofLargeReservoirsbySixuanLi,LinglingZhu,JingYuan,BingjiangDong,ChaonanLvandChenggangYangSustainability2024,16(24),;doi.org/10.3390/su5(registering DOI)-21Dec2024AbstractTheoperationoflargereservoirssignificantlymodifiesflow–sedimentregimes,andthereachesimmediatelydownstreamofthedamsarethefirsttoundergoresponsivechanneladjustments.Consideringthatthegeomorphologicalresponsesaredirectlyrelatedtothefloodcontrolsafety,channelstabilityandothersustainable[...]Readmore.Theoperationoflargereservoirssignificantlymodifiesflow–sedimentregimes,andthereachesimmediatelydownstreamofthedamsarethefirsttoundergoresponsivechanneladjustments.Consideringthatthegeomorphologicalresponsesaredirectlyrelatedtothefloodcontrolsafety,channelstabilityandothersustainablefunctionsofrivers,thispaperexploresthesimilaritiesanddissimilaritiesofthechanneladjustmentsinthetworeacheswithgrel–sandbedsimmediatelydownstreamoftheXiangjiabareservoirandtheThreeGorgesDam,respectively.Theresultsshowthatmajorerosionprimarilyoccurredduringtheinitialyearsofreservoirimpoundment.Andthenwiththeprominentreductioninwashablesedimentontheriverbed,theerosionintensityfurtherweakened.Ittakes6to13yearsforthetworeachestoreachanewstateofrelativeequilibrium.Incomparison,aftertheequilibriumstatehasbeenachieved,thereachwithsignificanttributarysedimentinflowsexhibitsalternatingerosionanddepositiondynamics,whiletheotherremainsrelativelystable.ThetributariesthattransportalargeamountofsedimentduringfloodsarethemainsourcesofsedimentdepositioninthedownstreamreachesoftheXiangjiabareservoir.However,thetributaryinflowoftheQingRiverwithlowsedimentconcentrationshaslittleimpactontheriverbedevolutionofthereachesfromYichangtoZhichengimmediatelydownstreamoftheThreeGorgesDam.Thesefindingscontributetoadeeperunderstandingofgeomorphicadjustmentsneardamsinresponsetoupstreamdamming.Fullarticle(ThisarticlebelongstotheSpecialIssueSedimentMovement,SustainableWaterConservancyandWaterTransport)17pes,2079KiB OpenAccessArticleOptimizingCryopreservationProtocolsforCoffearacemosaandCoffealiberica:ImpactofMoistureContentandPackingonSeedViabilitybyStefaniaVilasBoasCoelho,SttelaDellyzeteVeigaFrancodaRosa,LilianPadilha,JanainaGuarieiroRibeirodeAssis,AnaLuizadeOliveiraVilela,AnaMariaOliveiraFerreira,OliveiroGuerreiroFilhoandMasakoTomaBrhinironomy2024,14(12),3058;doi.org/10.3390/ronomy(registering DOI)-21Dec2024AbstractCryopreservationprotocolshenotyetbeendefinedforseedsofsomeCoffeaspeciesduetotheirhighsensitivitytodesiccationandtoultra-lowtemperatures,factorsthatleadtolowseedsurvivalratesafterwarming.Thisreducedrateoccursduetoseveralfactorsthat[...]Readmore.CryopreservationprotocolshenotyetbeendefinedforseedsofsomeCoffeaspeciesduetotheirhighsensitivitytodesiccationandtoultra-lowtemperatures,factorsthatleadtolowseedsurvivalratesafterwarming.Thisreducedrateoccursduetoseveralfactorsthatcompromisecellularintegrityduringthestepsoftheprocess.Inthisstudy,weevaluatedtheeffectofmoisturecontentandthetypesofpackingonthecryopreservationofCoffearacemosaandCoffealibericavardewevreiseeds.Forthatpurpose,seedsweredriedtomoisturecontentsof18,20,and25%(drybasis—db)forC.racemosaandtocontentsof20,25,30,and35%forC.liberica.Theseedswerethenpackedinmeshbs,Falcontubes,andtriple-laminatedaluminumfoilpouchesbeforebeingdirectlyimmersedinliquidnitrogen.Physiologicalandbiochemicalanalyseswereperformedontheseeds.Therewasinteractionbetweenmoisturecontentandthepackingoftheseedsofthespecies.Dryingtheseedstoa20%moisturecontentandpackingthemintriple-laminatedaluminumfoilpouchesprovidedthebestcryopreservationprotocolamongthosestudied,withsurvivalratesof79and8%forC.racemosaandC.liberica,respectively.Fullarticle(ThisarticlebelongstotheSectionroecologyInnovation:AchievingSystemResilience)20pes,319KiB OpenAccessArticleLyapunovInequalitiesforSystemsofTemperedFractionalDifferentialEquationswithMulti-PointCoupledBoundaryConditionsviaaFixPointApproachbyHailongMaandHongyuLiFractalFract.2024,8(12),754;doi.org/10.3390/fractalfract(registering DOI)-21Dec2024AbstractInthispaper,westudyasystemofnonlineartemperedfractionaldifferentialequationswithmulti-pointcoupledboundaryconditions.ByapplyingthepropertiesofGreen’sfunctionandtheoperatorandcombiningthemethodofmatrixanalysis,weobtainthecorrespondingLyapunovinequalitiesundertwo[...]Readmore.Inthispaper,westudyasystemofnonlineartemperedfractionaldifferentialequationswithmulti-pointcoupledboundaryconditions.ByapplyingthepropertiesofGreen’sfunctionandtheoperatorandcombiningthemethodofmatrixanalysis,weobtainthecorrespondingLyapunovinequalitiesundertwoBanachspaces.And,wehecomparedtwoLyapunovinequalitiesundercertainconditions.Anexampleisgiventoverifyourresults.Fullarticle(ThisarticlebelongstotheSpecialIssueNonlinearFractionalDifferentialEquationandFixed-PointTheory)27pes,865KiB OpenAccessArticleSensitivityAnalysisofFactorsInfluencingCoalPricesinChinabyJingyeLyu,ChongLi,WenwenZhouandJinsuoZhangMathematics2024,12(24),4019;doi.org/10.3390/math(registering DOI)-21Dec2024AbstractAscientificassessmentofthesensitivityoftheChinesecoalmarkethasbecomeanimportantresearchtopic.ThispapercombinesGaussianProcessRegression(GPR)andSobolsensitivityanalysistoconstructaGPR–SobolhybridmodelinnovativelyappliedtotheChinesecoalmarket,thusaddressing[...]Readmore.AscientificassessmentofthesensitivityoftheChinesecoalmarkethasbecomeanimportantresearchtopic.ThispapercombinesGaussianProcessRegression(GPR)andSobolsensitivityanalysistoconstructaGPR–SobolhybridmodelinnovativelyappliedtotheChinesecoalmarket,thusaddressingagapintheeconomicapplicationsofthismethod.ThemodelisusedtoanalyzethesensitivityoffactorsinfluencingcoalpricesinChina.TheGPR–Sobolmodeleffectivelyhandlesnonlinearrelationships,enablinganin-depthexplorationofkeyfactorsaffectingpricevolatilityandquantifyingtheirimpacts,thusovercomingthelimitationsoftraditionaleconometricmodelsinnonlineardataprocessing.Theresultsindicatethateconomicgrowth,energyprices,interestrates,exchangerates,anduncertaintyfactorsexhibithighsensitivityandsignificantlyimpactcoalpricefluctuationsinChina.CoalpricesinnorthwestChinaaremoresensitivetointerestratesandgeopoliticalrisks,whilepricesineastandsouthChinaaremoreresponsivetoexchangeratesbutlesssotoeconomicpolicyuncertainty.Additionally,coalpricesinnorth,south,andeastChinaarehighlysensitivetointernationalenergyprices,indicatingthatcoalpricesaredominatedbytheglobalenergymarket,yettheirweakresponsetomacroeconomicindicatorssuggeststheseregionsisstillinsufficientlymature.Fullarticle15pes,KiB OpenAccessArticleFlow-InducedFatigueDameofLargeFrancisTurbinesUnderMultipleOperatingLoadsbyPinghuLiu,XingxingHuang,TianyuYangandZhengweiWangAppl.Sci.2024,14(24),;doi.org/10.3390/app3(registering DOI)-21Dec2024AbstractTheFrancisrunnerisacriticalcomponentoftheFrancisturbinegeneratorunit,playingacentralroleinconvertingwaterenergyintorotatingmechanicalenergythatdrivesthegeneratorinhydropowerstations.In-depthanalysesoftheflowcharacteristicsoftheFrancisrunnerunder[...]Readmore.TheFrancisrunnerisacriticalcomponentoftheFrancisturbinegeneratorunit,playingacentralroleinconvertingwaterenergyintorotatingmechanicalenergythatdrivesthegeneratorinhydropowerstations.In-depthanalysesoftheflowcharacteristicsoftheFrancisrunnerundervariousoperatingconditionsandoidingfatiguedameoftheFrancisrunnerarecrucialtothereliabilityandefficiencyofhydropoweroperation.Inthispaper,theflowdynamicsofalargeFrancisturbinerunnerareanalyzedunderthreerepresentativeloadingconditions—lowpartialload,highpartialload,andfullload—andtheflow-inducedstressoftherunnerisanalyzedundertheseloadingconditions.Itwasfoundthatthemaximumstaticanddynamicsstressesoftherunneratthreerepresentativeloadingconditionsarelocatedatthechamferedsurfacewherethebladetrailingedgeconnectstotherunnercrown.ThemaximumstaticstressesoftheFrancisrunnerare284MPa,352MPa,and381MPaatlowpartialload,highpartialload,andfullload,respectively,andtheyareabovetheallowablestresslimits,ashalfoftheyieldstressoftherunnermaterialof550MPa.Thepeak-to-peakvaluesofrunnerdynamicstressatlowpartialload,highpartialload,andfullloadare15MPa,25MPa,and14.6MPa,respectively.Thehighstressinvokedbytheunsteadyflowundervariousloadingconditionsinthisrunnerwasthecauseofthefatiguebreakeoftherunnerblades.TheresultsofthisinvestigationheimportantreferencevaluesformitigatingfatiguedameinsimilarFrancisrunnersandoptimizingunitoperation.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancedTechnologiesinRotatingMachinery:Design,Modeling,Manufacturing,Testing,andOperation)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,8003KiB)15pes,6121KiB OpenAccessArticleNetworkToxicologyandMolecularDockingAnalysisofTetracycline-InducedAcutePancreatitis:UnveilingCoreMechanismsandTargetsbyHangLei,YimaoWu,WenjunMa,JiaqiYao,PengchengZhang,YongTian,YuhongJiang,ZhijunXie,LvZhuandWenfuTangToxics2024,12(12),929;doi.org/10.3390/toxics(registering DOI)-21Dec2024AbstractAcutepancreatitis(AP),inducedbytetracycline,awidelyusedantibiotic,posessignificantclinicalandtoxicologicalchallenges,yetitsmolecularmechanismsremainunclear.Thisstudyaimstopromotedrugtoxicologystrategiesfortheeffectiveinvestigationoftheputativetoxicityandpotentialmolecularmechanismsof[...]Readmore.Acutepancreatitis(AP),inducedbytetracycline,awidelyusedantibiotic,posessignificantclinicalandtoxicologicalchallenges,yetitsmolecularmechanismsremainunclear.ThisstudyaimstopromotedrugtoxicologystrategiesfortheeffectiveinvestigationoftheputativetoxicityandpotentialmolecularmechanismsofantibioticdrugsthroughthestudyoftetracyclineinAP.UsingtheSwissTargetPrediction,SEASearch,Super-PRED,GeneCards,Drugbank,OnlineMendelianInheritanceinMan(OMIM),andTherapeuticTargetDatabase(TTD),weidentified259potentialtargetsassociatedwithtetracyclineexposureandAP.FurtherrefinementviatheSTRINGdatabaseandCytoscape(version3.10.1)softwarehighlighted22coretargets,includingTP53,TNF,andAKT1.FunctionalenrichmentviatheDatabaseforAnnotation,Visualization,andIntegratedDiscovery(DID)identifiedpathwaysthroughGeneOntology(GO)termsandtheKyotoEncyclopediaofGenesandGenomes(KEGG)database,highlightingPI3K-Akt,MAPK,HIF-1,andE-REascriticalmediatorsintetracycline-inducedAP.Moleculardockingconfirmedthestrongbindingbetweentetracyclineandthecoretargets.Overall,thesefindingssuggestthattetracyclinemayaffecttheoccurrenceandprogressionofpancreas-relatedinflammationbyregulatingpancreaticcellapoptosisandproliferation,activatinginflammatorysignalingpathways,andregulatinglipidmetabolicpathways.Thisstudyprovidesatheoreticalbasisforunderstandingthemolecularmechanismoftetracycline-inducedAPandlaysthefoundationforthepreventionandtreatmentofdigestivesystemdiseasesassociatedwithexcessiveexposuretotetracyclineantibioticsandcertaintetracyclines.Inaddition,ournetworktoxicologyapproachhasacceleratedtheelucidationoftoxicpathwaysinantibioticdrugsthatlackspecificcharacteristics.Fullarticle(ThisarticlebelongstotheSpecialIssueState-of-the-ArtEnvironmentalChemicalExposomicsandMetabolomics—2ndEdition)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure5Cont.---Figure6---Figure7---Figure7Cont.19pes,1643KiB OpenAccessArticleAnalysisofSelectedITToolsforEnvironmentalProductAssessmentbyDamianGrajewski,AnnaDudkowiak,MiłoszWiśniewskiandEwaDostatniAppl.Sci.2024,14(24),;doi.org/10.3390/app2(registering DOI)-21Dec2024AbstractThisarticlediscussesthesubjectoftheenvironmentalassessmentofproductsbasedonspecificmethods(LCA,ReCiPe,andSM2013)andtools(GaBi,SimaPro,andSustainableMinds).TheaimofthisworkwastoanalyzeselectedITtoolsforsupportingsuchanassessment.Assumptions[...]Readmore.Thisarticlediscussesthesubjectoftheenvironmentalassessmentofproductsbasedonspecificmethods(LCA,ReCiPe,andSM2013)andtools(GaBi,SimaPro,andSustainableMinds).TheaimofthisworkwastoanalyzeselectedITtoolsforsupportingsuchanassessment.Assumptionsandcriteriawereadopted,basedonwhichspecificITtoolswereselectedforacomparativeanalysis.Then,anenvironmentalassessmentofreferenceproductswascarriedoutusingthreedifferentITtools.Thestructureoftheproductswaspreparedinsuchawaythatthepartsandsubassembliesmettwobasicrequirements.First,theyweremadeofconstructionmaterialsthataregenerallyailableandusedinindustry.Thesecondrequirementwasthatthetechnologiesformanufacturingthesepartsincludedasmanyfrequentlyusedtechnologicalprocessesaspossible.ThisallowedforacomparisonoftheresultsofestimatedenvironmentalassessmentsgeneratedbyselectedITtools.Asaresult,thestrengthsandweaknessesofeachoftheITtoolswereidentified.Fullarticle(ThisarticlebelongstotheSectionEnvironmentalSciences)23pes,KiB OpenAccessArticleDynamicsModelandItsVerificationofAerospaceThree-RingGearReducerbyJinyongLai,LanLuo,GuangzhaoLuoandShiyuanChaoAerospace2024,11(12),1049;doi.org/10.3390/aerospace(registering DOI)-21Dec2024AbstractThispaperproposesanonlineardynamicmodelingmethodbasedonthelumpedmassapproachtoaddressthechallengeofmodelingthevibrationsoftheoutputexternalgearandinternalgearplateinanaerospacethree-ringgearreducer.Avibrationmodelofbending–torsioncoupling[...]Readmore.Thispaperproposesanonlineardynamicmodelingmethodbasedonthelumpedmassapproachtoaddressthechallengeofmodelingthevibrationsoftheoutputexternalgearandinternalgearplateinanaerospacethree-ringgearreducer.Avibrationmodelofbending–torsioncouplingwith12degreesoffreedomwasestablishedbycomprehensivelyconsideringfactorssuchasthetime-varyingmeshingstiffness,geartransmissionerror,toothsideclearance,bearingsupportstiffness,anddamping.Finiteelementmodalanalysisandvibrationtestresultsverifiedthevibrationmodel’saccuracyandapplicability,indicatingthatthemodelisbothpreciseandvalid.Thevibrationmodelwassolvedusingthefourth-order,five-levelRunge–Kuttamethod.Theresultsshowthatthesymmetricalarrangementdesignoftheinternalgearplatecancelsthevibrationsinalldirectionsandsuppressesthevibrationdisplacementresponseontheoutputshaft.Fullarticle(ThisarticlebelongstotheSectionAeronautics)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure6Cont.---Figure7---Figure8---Figure9---Figure10---Figure11---Figure11Cont.---Figure12---Figure12Cont.---Figure13---Figure14---Figure15---Figure16---Figure1731pes,1334KiB OpenAccessArticleEmpoweringNanostoresforCompetitivenessandSustainableCommunitiesinEmergingCountries:AGenerativeArtificialIntelligenceStrategyIdeationProcessbyDidErnestoSalinas-Narro,EliseoVilalta-PerdomoandRosarioMichel-VillarrealSustainability2024,16(24),;doi.org/10.3390/su4(registering DOI)-21Dec2024AbstractThisexploratorystudyinvestigatesGenerativeArtificialIntelligence’s(GenAI)useinstrategyideationfornanostores—i.e.,smallindependentgroceryretailers—toenhancetheircompetitivenesswhilecontributingtocommunitysustainability.Nanostores,particularlyinemergingcountries,faceintensecompetitionandrapidlychangingtrends.Thesestoresadoptvariousstrategies[...]Readmore.ThisexploratorystudyinvestigatesGenerativeArtificialIntelligence’s(GenAI)useinstrategyideationfornanostores—i.e.,smallindependentgroceryretailers—toenhancetheircompetitivenesswhilecontributingtocommunitysustainability.Nanostores,particularlyinemergingcountries,faceintensecompetitionandrapidlychangingtrends.Thesestoresadoptvariousstrategiesbyleveringtheirproximitytoconsumersinneighbourhoods,resultingindifferentbusinessconfigurations.Whiletheexistingliteraturehighlightsthebroadernanostores’functions,thereislimitedresearchonhowtheymaydevelopcomprehensivestrategiestofacetheirchallenges.Byemployingathingethnographymethodology,thisworkproposesGenAIthinginterviewing—i.e.,withChatGPT3.5andMicrosoftCopilot—throughincrementalpromptingtoexplorepotentialstrategyideationandpractices.KeyfindingssuggestGenAIconversationscanaidshopkeepersinstrategyideationthroughhuman-likewrittenlangue,aligningwithsmallbusinessdynamicsandstructures.ThispropositionresulBitte 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(im Kombibereich) WolkentsinaGenAIideationframeworkforstrategygenerationanddefinition.Moreover,thistechnologycanenhancenanostorecompetitivenessandsustainabilityimpactbyenactingimprovedstrategypracticesinstakeholderengements.Accordingly,thiswork’smaincontributionunderscoresaGenAI-enabledconversationalapproachtofacilitatenanostores’strategyideationandembeddingineverydaybusinessoperations.FutureworkmustaddressthelimitationsandfurtherinvestigateGenAI’sinfluenceonhumanunderstandingandtechnologicalcreation,strategyideation,adoption,andusabilityinnanostores.Fullarticle(ThisarticlebelongstotheSpecialIssueSmallandMediumEnterprises:GreenOrientationsandSustainableBusinessModels)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,982KiB)19pes,6777KiB OpenAccessArticleCurcuminandMetforminInfiniteCoordinationPolymerNanoparticlesforCombinedTherapyofDiabeticMiceviaIntraperitonealInjectionsbySiweiSun,XinyiHou,KeLi,ChenqiHuang,YuRong,JiaoBi,XuepingLiandDaochengWuJ.Funct.Biomater.2024,15(12),388;doi.org/10.3390/jfb(registering DOI)-21Dec2024AbstractMetformin(Met)isoneofthemostcommonlyprescribedfirst-linedrugsfordiabetestreatment.However,ithasseveralissues,includinglowbioailability,therapeuticplatform,andsideeffectsathighdoses.InordertoimprovethetherapeuticefficiencyofMet,thisstudyproposesa[...]Readmore.Metformin(Met)isoneofthemostcommonlyprescribedfirst-linedrugsfordiabetestreatment.However,ithasseveralissues,includinglowbioailability,therapeuticplatform,andsideeffectsathighdoses.InordertoimprovethetherapeuticefficiencyofMet,thisstudyproposesastrategyofusingMetandcurcumin(Cur)toprepareCur-Zn(II)-Metinfinitecoordinationpolymernanoparticles(CMICPNPs),andcombiningthiswithintraperitonealinjections,forthetreatmentofdiabeticmice.Fouriertransforminfrared(FTIR)spectroscopy,X-rayphotoelectronspectroscopy(XPS),transmissionelectronmicroscopy(TEM),nanoparticleanalysis,cytotoxicityexperiments,andmiceexperimentswereusedtoinvestigatestructure,properties,andapplicationeffects.TheresultsshowedthatCMICPNPsexhibitahighdrugencapsulationrate(100%),goodstability,andanabsenceofinvivoandinvitrotoxicity.Thebloodglucoselevelofdiabeticmiceaftertreatmentwasreducedto6.7±0.65mmol/Lattheseventhweek.Intermsoftherapeuticmechanism,itappearsthatMetandCurcansynergisticallyregulatebloodglucoseinmicefrommultiplepaths.ThisstudyprovidesapromisingmethodforthetreatmentofdiabetesusingMetandotherdrugs.Fullarticle(ThisarticlebelongstotheSpecialIssueStateoftheArtinBiomaterialsforDrugDelivery)14pes,306KiB OpenAccessArticleNutritionalStatusofVeryElderlyOutpatientswithHeartFailureandItsInfluenceonPrognosisbySoniaGonzález-Sosa,PabloSantana-Vega,AlbaRodríguez-Quintana,JoseA.Rodríguez-González,JoséM.García-Vallejo,AliciaPuente-FernándezandAliciaConde-MartelNutrients2024,16(24),4401;doi.org/10.3390/nu(registering DOI)-21Dec2024AbstractAbstracts:Background/Objectives:Malnutritionhasbeenassociatedwithincreasedmorbidityandmortalityinelderlypatientsdinosedwithheartfailure(HF)[...]Fullarticle(ThisarticlebelongstotheSectionClinicalNutrition)MoreArticles...OpenAccessJournalsAcousticsActaMicrobiologicaHellenica(AMH)ActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicine(ARM)AerobiologyAerospacericultureriEngineeringrochemicalsronomyAIAirAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnesthesiaResearchAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBlockchainsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicalBioenergeticsClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesComplicationsCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryoCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilitiesDiseasesDiversityDNADronesDrugsandDrugCandidates(DDC)DynamicsEarthEcologiesEconometricsEconomiesEducationSciencesElectricityElectrochemElectronicMaterialsElectronicsEmergencyCareandMedicineEncyclopediaEndocrinesEnergiesEnergyStoreandApplications(ESA)EngEngineeringProceedingsEntropyEnvironmentalandEarthSciencesProceedingsEnvironmentsEpidemiologiaEpigenomesEuropeanBurnJournal(EBJ)EuropeanJournalofInvestigationinHealth,PsychologyandEducation(EJIHPE)FermentationFibersFinTechFir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